Unlocking the Mystery of Ureaplasma
A female medical care professional in a black scrub top is smiling for the camera.

Here at Almond, we are noticing a real uptick in women inquiring about Ureaplasma. Let’s clarify some of the misconceptions associated with this bacteria, what it is, when to treat it and understanding the mystery behind it! 


Vaginal Microbiome


Before delving into Ureaplasma, it is important to understand the woman’s vaginal microbiome; it is an intricate and dynamic micro ecosystem that constantly undergoes fluctuations during the female menstrual cycle and a woman’s entire life. A healthy vaginal microbiome is dominated by Lactobacillus, which produces various antimicrobial compounds. One of the benefits of Lactobacillus is that it produces lactic acid and other organic acids, which help maintain an acidic pH that inhibits the growth of harmful bacteria. Additionally, Lactobacilli produce antimicrobial compounds and compete with unwanted microorganisms for resources. 


The bottom line–our vaginal microbiome serves as a natural defense mechanism against infections, including sexually transmitted infections (STIs) and urinary tract infections (UTIs). When it is not well balanced, it can lead to health problems and vaginal infections. 


How Does Ureaplasma Play into Our Vaginal Microbiome? 


Ureaplasma, a genus of bacteria, belongs to the class Mollicutes, known for their minimal cell walls and lack of a rigid cell structure. M. hominis and Ureaplasma spp are part of the normal genital flora of many sexually experienced males and females. The percentage of females with these organisms increases after puberty in direct correlation to the number of lifetime sexual partners. By adulthood, up to 80 percent of healthy females have Ureaplasma spp, and 50 percent have M. hominis in their cervical or vaginal secretions. So if you are very sexually active, chances are, you have more ureaplasma in your vaginal biome! 


Ureaplasma colonization, whereby the bacteria reside in the urogenital tract without causing symptoms, is relatively common, as mentioned above. It is for this reason that clinicians are not treating every patient with positive Ureaplasma. 


When ureaplasma overgrows or disrupts the delicate balance of the vaginal microbiome, it can present with signs and symptoms related to other vaginal infections which will require treatment. Signs and symptoms such as: increased vaginal discharge, foul smelling discharge, pelvic pain and/or urinary pain and frequency are signs and symptoms whereby vaginal and urinary testing are warranted. 


What is the bottom line on Ureaplasma? 


Diagnosing ureaplasma infections can be challenging because they often present with nonspecific symptoms that overlap with other urogenital conditions due to a disruption in our natural flora. 


Ureaplasma, while it may be a trending health topic, is rarely a solitary diagnosis. Furthermore, understanding the complex interplay between ureaplasma, the vaginal microbiome, and the body's defense system is essential for developing a care plan. 


Routine screening for ureaplasma infections is not universally recommended, but it may be considered in certain populations, such as pregnant women with a history of preterm birth (there is increased incidence of preterm birth when high levels of ureaplasma are noted) or individuals with recurrent urogenital symptoms.


Prevention and Management


What can we do to help keep our biome healthy? Preventing an increase of unhealthy bacteria often involves practicing good genital hygiene, using condoms during sexual intercourse, and avoiding multiple sexual partners. Regular screening for sexually transmitted infections (STIs) is also essential, especially for individuals at higher risk.


For women diagnosed with recurrent vaginal infections, managing the condition may require a multifaceted approach, including:


  • Immune Support: Boosting the immune system through a healthy diet, vaginal probiotics, regular exercise, and adequate rest.
  • Lifestyle Modifications: Avoiding irritants such as douches, scented feminine products, and tight-fitting clothing that can disrupt the vaginal microbiota.
  • Partner Treatment: Ensuring that sexual partners are tested for STIs and treated to prevent reinfection.


Understanding Ureaplasma and its influence on women's health highlights the significance of nurturing a healthy vaginal microbiome and taking proactive steps to safeguard reproductive well-being. At Almond, we prioritize open communication with your healthcare provider to address any medical concerns and ensure the effective management of your medical care.

Regular check-ups, safe sexual practices, and a healthy lifestyle are key to preventing and managing infections. Stay informed, stay proactive, and never hesitate to seek medical guidance. At Almond, we are here to help! 


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